MicroED <span>Service</span>


Accelerate structure determination of nanocrystals
Explore the frontier of molecular structure and function with Microcrystal Electron Diffraction (MicroED) technology. This cutting-edge technique unveils the 3D structures of nanoscale molecules, considered a disruptive tool at the foundational level in fields such as chemistry, synthesis, biology, and more.
MicroED employs electron beams to generate crystal diffraction patterns, enabling precise determination of crystal structures. Thanks to the superior electron-matter interaction compared to X-rays, MicroED achieves high-resolution results with tiny crystals, minimizing sample requirements.
Pioneered by the ReadCrystal team, stemming from Stockholm University's MicroED tech developers, we proudly present the world's first commercial MicroED platform. Our innovation includes advanced technology enhancements and proprietary software for swift, accurate 3D structure determination, even for challenging samples with limited crystal size and purity.
Confirmation of small molecule structures
In the preclinical research phase of a drug, the structure of a compound needs to be confirmed. For some microcrystalline particles whose structures cannot be resolved using single-crystal X-rays, MicroED is your best choice. In the field of pharmaceutical small molecules, MicroED offers:

Structure Determination of Powder Drug

Structure Determination of Co-crystal Drug

Absolute Configuration Confirmation

Analyzing the molecular structure of materials
It is challenging to cultivate large single crystals for cutting-edge materials. However, MicroED technology offers a breakthrough by enabling the analysis of nanocrystal structures as small as 100nm. This greatly reduces the difficulty and time for crystal cultivation. MicroED is often used for analyzing material-related fields:

Framework materials, such as MOFs, COFs, HOFs, Zeolites, etc.

Battery materials, such as LCO, etc.

Other microcrystalline materials

Structure determined by ReadCrystal
  • 300+
    Drug Molecules
  • 150+
    Frame Materials
  • 100+
    Battery Materials
  • 50+
    Other Materials
  • Micro-sized crystals

    Required crystal size: >50μm

  • High sample consumption

    Required samples: >200mg

  • High sample purity requirements

    Testing must be conducted using pure-phase samples

  • Absolute configuration

    Resolving the absolute configuration of chiral compounds through the principle of anomalous dispersion

  • Nano-sized crystals

    Resolution achievable with samples of crystals as small as 100nm; Applicable to nanocrystals/powder crystals/needle-shaped crystals

  • Low sample consumption

    Minimal consumption of sample (as low as 2mg)

  • Low sample purity requirements

    For mixed-phase samples, the independent structures of all pure phases are directly resolved.

  • Absolute configuration

    Confirming the absolute configuration of chiral compounds through dynamic refinement

Deliver structure within one week
  • Sample Preparation
  • Sample Test
  • Electron Diffraction Data Collection
  • Data Analysis
Case Studies