HTS
HTS

High Throughput Screening (HTS) is a cornerstone of modern drug discovery, enabling rapid evaluation of large compound libraries to identify potential drug candidates.

Key Features

Automated Screening Platforms

State-of-the-art robotic systems allow us to screen millions of compounds in a short period.

Diverse Compound Libraries

Our extensive libraries include natural products, synthetic compounds, and drug-like molecules, ensuring comprehensive coverage.

Secondary Screening

Follow-up assays validate hits and elucidate mechanisms of action, reducing false positives.

Technical Workflow
01
Target Acquisition & Library Selection
    • Our meticulously curated compound library, encompassing natural products, synthetic molecules, and combinatorial libraries, is designed to cover a wide range of chemical structures and properties. The biological target, such as a protein, enzyme, or cell line, is carefully prepared, immobilized on a suitable screening platform, and rigorously validated to ensure its relevance and activity in the screening assay.
02
Assay Development&Optimization
    • Select the target (enzyme, receptor, channel, etc.) and the detection mechanism (fluorescence, luminescence, colorimetry).
    • Optimize the signal-to-background ratio (S/B) and the Z' factor to ensure the stability of the experiment.
03
Automated Screening
    • Compound sample addition and reaction solution distribution are completed using an automated platform
    • Support parallel operation of 96/384/1536 well plates
04
Data Analysis&Hit Screening
    • Utilize multimode detectors to read signals such as chemiluminescence, fluorescence, and absorbance. 
    • Connect to high-throughput cell imaging systems for complex phenotypic detection. 
    • Set thresholds (e.g., 3σ) to screen for potentially active hits.