We Use Cookies And other Technology To Provide You With Our Services And For Functional. Analytical And Advertising Purposes. Please, Read Our Privacy Policy For More information.

Decline

Accept

EN / CN
MicroED
MicroED

MicroED (Microcrystal-Electron Diffraction) is an advanced technique that achieves structural analysis of proteins with small crystals by detecting electron diffraction patterns, providing high-resolution data.

Suitable for

Small proteins or fragments forming microcrystals

Proteins in low quantities or with tiny crystals

Radiation-sensitive proteins

Technical Workflow
01
Crystallization screening
    • High-throughput screening
    • 1800+ conditions tested in parallel
    • Mosquito robot ensure scalability and precision
    • Microsized protein crystal obtained

VIEW MORE
02
Vitrification
    • Rapid sample frozen conducted by Vit-robot
03
Cryo-FIB milling to nanosized crystals
    • The sample is cut or thinned using a focused ion beam to prepare ultrathin sections suitable for transmission electron microscopy (TEM) or other microscopic imaging techniques.
04
Data acquisition
    • In house MicroED device coupled with pioneering procession electron diffraction system is used for data collection.
05
Data processing & Modeling refinement
    • Analyza, is used for crystal structure analysis，efficiently handles data processing and refinement. It indexes diffraction patterns to determine unit cell parameters and confirms space group via systematic absences. Analyza extracts intensities with corrections, solves the structure to build an initial model, and refines it using least-squares, optimizing atomic positions and thermal parameters.
Case Studies
IL5Rα

VIEW MORE