Publications

Actinomycetes-derived imine reductases with a preference towards bulky amine substrates

Commun Chem. 2022 Oct 8;5(1):123. doi: 10.1038/s42004-022-00743

This paper reported the imine reductase IR-G02,which is capable of accepting bulky amine substrates.

ReadCrystal contribution:Structural biology related work of IR-G02 such as structure determination.

Atomic-resolution structures from polycrystalline covalent organic frameworks with enhanced cryo-cRED

Nat Commun. 2022 Jul 11;13(1):4016. doi: 10.1038/s41467-022-31524-9.

In this paper, a method is established to determine the structure of polycrystalline 3D COF at atomic level using enhanced cryo-continuous rotation electron diffraction (cryo-cRED).

This method was proposed by the team of Prof. Junliang Sun, the founder of ReadCrystal.

Studies on the Crystal Forms of Istradefylline: Structure, Solubility, and Dissolution Profile

Crystals. 2022, 12(7), 917; https://doi.org/10.3390/cryst12070917

Istradefylline as a selective adenosine A2A-receptor antagonist is clinically used to treat Parkinson’s disease. In this paper, its crystal forms were studied.

ReadCrystal contribution: study of crystal form, such as crystal preparation and structure determination.

Design and Synthesis of a Zeolitic Organic Framework

Angew Chem Int Ed Engl . 2022 Jun 13;61(24):e202203584. doi: 10.1002/anie.202203584.

In this paper, the first example of a 3D covalent organic framework with zeolitic network, namely the zeolitic organic framework (ZOF), ZOF-1 was reported. Its structure was determined by MicroED technique.

Structure determination of MicroED in this paper was done by the team of Prof. Junliang Sun, the founder of ReadCrystal.

Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering

Angew Chem Int Ed Engl . 2022 Jun 13;61(24):e202201908. doi: 10.1002/anie.202201908. Epub 2022 Apr 7.

In this paper, a concise strategy combining rational cavity design, combinatorial active-site saturation test (CAST), and thermostability engineering was designed to transformed the weakly active imine reductase IR-G36 into a variant M5 with superior performance.

ReadCrystal contribution: Structural biology related work of IR-G35 and M5 mutation such as protein expression and structure determination.

Structural origin of the high-voltage instability of lithium cobalt oxide

Nat Nanotechnol . 2021 May;16(5):599-605. doi: 10.1038/s41565-021-00855-x.

This paper reported structural differences at the atomistic level between two commercial LCO materials: a normal LCO (N-LCO) and a H-LCO.

Structure determination of LCO was done by the team of Prof. Junliang Sun, the founder of ReadCrystal. Three-dimensional continuous rotation electron diffraction method was used to determine the structure, also called MicroED.