Publications

A zeolite family with expanding structural complexity and embedded isoreticular structures

Nature. 2015 Aug 6;524(7563):74-8. doi: 10.1038/nature14575.

Structure of zeolite ZSM-25 was determined by MicroED technique in this paper.

The work related to structure determination was supported by Dr. Leifeng Liu, founder of ReadCrystal.

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Cell. 2012 Jan 20;148(1-2):213-27. doi: 10.1016/j.cell.2011.11.031.

This paper reported the important role of MLKL protein in cell necrosis, which functioned as a substrate of RIP3 kinase in RIP3-mediated cell necrosis signaling pathway. And a small molecule was discovered that can inhibit cell necrosis by specifically recognizing MLKL to block the necrosis signaling.

This article was published by the collaboration between Prof. Xiaodong Wang and Prof. Xiaoguang Lei's team, the founder of ReadCrystal.

The ITQ-37 mesoporous chiral zeolite

Nature. 2009 Apr 30;458(7242):1154-7. doi: 10.1038/nature07957.

In this paper, the structure of ITQ-37, the first chiral zeolite with one single gyroidal channel, was determined by SAED combined with PXRD.

The work in this paper was done by Professor Sun Junliang, the founder of ReadCrystal.

Comprehensive analysis of Enterobacteriaceae IncX plasmids reveals robust conjugation regulators PrfaH, H-NS, and conjugation-fitness tradeoff

Commun Biol . 2025 Mar 4;8(1):363. doi: 10.1038/s42003-025-07782-w.

This study comprehensively analyzed IncX plasmids in Enterobacteriaceae, revealing that the plasmid-encoded activator PrfaH and inhibitor H-NS are key factors regulating their conjugative transfer and indicating that PrfaH may be a potential target for combating antibiotic resistance.

ReadCrystal's contribution: resolve the crystal structure of PrfaH, identifying the key residues mediating target interactions, and providing a structural basis.

Unconventional Heterobidentate Coordination of 4-Hydroxypyridine Leading to Remarkably Strong Second-Harmonic Generation in Zn(C5H4NO)2

Angew Chem Int Ed Engl . 2025 Feb 24;64(9):e202420810. doi: 10.1002/anie.202420810. Epub 2024 Dec 9.

This study reports that in the novel compound Zn(C₅H₄NO)₂, the unconventional heterobidentate coordination of 4-hydroxypyridine ligands with Zn²⁺ leads to uniform polarization alignment of [ZnO₂N₂] tetrahedral units, resulting in a remarkably strong second-harmonic generation, along with suitable optical band gap, high thermal stability, excellent air and water resistance, and photoluminescence with enhanced lifetime;

ReadCrystal's contribution: provide structural insights through MicroED

Engineered Metal-Organic Framework with Stereotactic Anchoring and Spatial Separation of Porphyrins for Amplified Ultrasound-Mediated Pyroptosis and Cancer Immunotherapy

Angew Chem Int Ed Engl . 2025 Mar 3;64(10):e202421402. doi: 10.1002/anie.202421402. Epub 2024 Nov 28.

This study designed a porphyrin-based metal-organic framework, Fe(TCPP)-MOF, which achieves stereospecific anchoring and spatial separation of porphyrins through a dual-solvent strategy. This avoids aggregation-induced quenching, enhances interaction with oxygen, generates a large amount of singlet oxygen under ultrasound activation, and accelerates the Fenton reaction to produce hydroxyl radicals.

ReadCrystal's contribution：assist in analyzing the regular rigid conformation of Fe(TCPP)-MOF through MicroED analysis.